Nioclean AD Gel contains a combination of adapalene and clindamycin. It is used to treat acne or pimples. Do not squeeze a pimple as it may lead to bacteria, pus spreading on the skin that can lead to the spread of acne and acne scar. It is meant only for external application and should be applied exactly as recommended by your doctor. Wash your hands before and after applying the gel. Avoid excessive use of makeup, other products on your skin when using this gel. It may take a few weeks to improve the symptoms but you need to complete the entire course of the medicine. Do not stop the medicine suddenly, even if you feel better, as it may increase the risk of reoccurrence of the symptoms.